Christopher M. Taylor Assistant Professor | ||
Department of Computer Science University of New Orleans 2000 Lakeshore Dr New Orleans, LA 70148 CERM 217 (Office Location) 504.280.2408 (Office Phone) 504.280.7228 (Fax) [mylastname] at cs.uno.edu |
Research Institute for Children Children's Hospital 200 Henry Clay Ave New Orleans, LA 70118 R&E 2217 (Office Location) 504.896.2184 (Office Phone) 504.894.5379 (Fax) c[mylastname] at chnola-research.org |
Biography | Research | Publications | Students | Courses | Personal | CV |
Dr. Christopher Taylor joined the Department of Computer Science at the University of New Orleans (UNO) as an assistant professor in August 2008. He is also affiliated with the Research Institute for Children, part of the Children's Hospital of New Orleans where his research activities are supported. He earned his Ph.D. and M.S. degrees in Computer Science from the University of Virginia. He graduated with honors from Mary Washington College (now known as University of Mary Washington) with a B.S. in Computer Science and Mathematics. He actively collaborates with biological researchers on the development of algorithms and analysis tools for high-throughput sequencing technologies. He is an Editorial Board Member of International Journal of Biometrics and Bioinformatics (IJBB) and a reviewer for several other well known journals such as PLoS ONE and Bioinformatics. He is a faculty mentor to our ACM Student Chapter and the coach of UNO's ACM International Collegiate Programming Contest Team.
My group is developing algorithms and tools for analysis of microbial community sequencing data in the context of the human microbiome. The analysis of the microbiome uses high-throughput sequencing to assay the composition of the bacteria living within and upon a host organism. Changes in this population have implications in general human health and disease and the analysis of this diverse microbiota presents unique computational challenges. The system we are developing allows for visualization and manipulation of sequencing results as well as hypothesis testing. The system is very flexible and integrates diversity analysis, rarefaction curves, relative abundance pie charts, dendrograms, dot plots, and other important measures of community differences into a graphical framework that is easy to use for biological researchers with little technical training.
RNA CoMPASS: RNA Comprehensive Multi-Processor Analysis System for Sequencing
My group is also developing algorithms and analysis tools for RNA-Sequencing. RNA-Sequencing involves the application of high-throughput sequencing to investigate the RNA present in a given sample. This provides biologists with a way to study the impact of various factors on the transcriptome but poses a variety of computational challenges including dealing with splice junctions when mapping back to the reference genome. We have merged the functionality of the PARSES system described below with this work on RNA-Sequencing to create a Comprehensive Multi-Processor Analysis System for Sequencing which we call RNA CoMPASS. This new system provides all-in-one functionality including the typical endogenous RNA-Sequencing analysis along with the investigation of exogenous sequences pioneered in PARSES. RNA CoMPASS is deployable on either a local cluster or a grid environment managed by PBS submission to accelerate the analysis of large sequencing studies.
PARSES: Pipeline for Analysis of RNA-Sequencing Exogenous Sequences
We developed PARSES to allow researchers to uncover and investigate sequences in their samples arising from organisms other than the host. This is a relatively understudied area of RNA-Sequence analysis as most researchers focus only on the sequences that map back to the host genome and discard any non-mapping reads. The PARSES system focuses instead on these reads which do not map to the host genome and performs an extensive analysis of these sequences to investigate their origin. The PARSES ssytem was designed to provide for an easy, automated installation and updating of existing system components as necessary.
Refereed Journal Articles:Refereed Conference Papers:
- Zhen Lin, Adriane Puetter, Joseph Coco, Guorong Xu, Michael Strong, Xia Wang, Claire Fewell, Melody Baddoo, Christopher Taylor and Erik Flemington.
Detection of Murine Leukemia Virus in the Epstein-Barr virus-positive human B-cell line JY using a computational RNA-seq based exogenous agent detection pipeline, PARSES.
J Virol. 2012 Mar;86(6):2970-7. Epub 2012 Jan 11. PMID: 22238296 [PubMed - in process]- Murat Eren, Marcela Zozaya, Christopher Taylor, Scott Dowd, David Martin and Michael Ferris.
Exploring the diversity of Gardnerella vaginalis in the genitourinary tract microbiota of monogamous couples through subtle nucleotide variation.
PLoS One. 2011;6(10):e26732. Epub 2011 Oct 25. PMID: 22046340 [PubMed - in process]- Nan Deng, Adriane Puetter, Kun Zhang, Kristen Johnson, Zhiyu Zhao, Christopher Taylor, Erik K. Flemington and Dongxiao Zhu.
Isoform-level microRNA-155 target prediction using RNA-seq.
Nucleic Acids Res. 2011 May;39(9):e61. Epub 2011 Feb 11. PMID: 21317189- Mignon A. Keaton, Christopher M. Taylor, Ryan M. Layer and Anindya Dutta.
Nuclear scaffold attachment sites within ENCODE regions associate with actively transcribed genes.
PLoS ONE. 2011 Mar 14;6(3):e17912. PMID: 21423757- Zhen Lin, Guorong Xu, Nan Deng, Christopher Taylor, Dongxiao Zhu and Erik K Flemington.
Quantitative and qualitative RNA-seq-based evaluation of Epstein-Barr virus transcription in type I latency Burkitt's lymphoma cells.
Journal of Virology. 2010 Dec;84(24):13053-8. PMID: 20943983- Guorong Xu, Claire Fewell, Christopher Taylor, Nan Deng, Dale Hedges, Xia Wang, Kun Zhang, Michelle Lacey, Haitao Zhang, Qinyan Yin, Jennifer Cameron, Zhen Lin, Dongxiao Zhu and Erik Flemington.
Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq.
RNA. 2010 Aug;16(8):1610-22. PMID: 20584899. PMCID: PMC2905759- Neerja Karnani, Christopher M. Taylor, Ankit Malhotra and Anindya Dutta.
Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selection.
Molecular Biology of the Cell. 2010 Feb;21(3):393-404. PMID: 19955211. PMCID: PMC2814785Invited Book Chapter:
- Joseph R. Coco, Erik K. Flemington, and Christopher M. Taylor.
PARSES: A Pipeline for Analysis of RNA-Seq Exogenous Sequences.
ISCA 3rd International Conference on Bioinformatics and Computational Biology. 2011:196-200. New Orleans, LA, March 2011.- A. Murat Eren, Michael J. Ferris, and Christopher M. Taylor.
A Framework for Analysis of Metagenomic Sequencing Data.
Pacific Symposium on Biocomputing. 2011:131-41. Kohala Coast, Hawaii, January 2011. PMID: 21121041
- Neerja Karnani, Christopher M. Taylor and Anindya Dutta.
Microarray Analysis of DNA Replication Timing.
Methods in Molecular Biology. 2009;556:191-203. ISBN: 978-1-60327-191-2, Humana Press. PMID: 19488880
Current Students:Former Students:
- Mohamad Qayoom - PhD Candidate at UNO
Mohamad is a contributor to the RNA CoMPASS project assisting with documentation and deployment
He is currently a Network Analyst at LSU Health Sciences Center in New Orleans, LA- Gene Blanchard - Undergraduate at UNO
Gene is a contributor to the Viamics project assisting with installation, packaging, and enhancement
He is currently an undergraduate computer science major at UNO
- Guorong Xu - PhD, June 18, 2012: RNA CoMPASS: RNA Comprehensive Multi-Processor Analysis System for Sequencing
Guorong was the primary developer for the RNA CoMPASS system for RNA-Sequencing analysis
He is now a Research Associate at Baylor Research Institute in Dallas, TX- "Meren" A. Murat Eren - PhD, April 6, 2011: Assessing Microbial Diversity Through Nucleotide Variation
Meren was the primary developer for the Viamics framework for microbial community analysis
He is now a Postdoctoral Scientist at the Josephine Bay Paul Center for Comparative Molecular Biology and Evolution in Woods Hole, MA- Joseph Coco - MS, April 11, 2011: PARSES: A Pipeline for Analysis of RNA-Sequencing Exogenous Sequences
Joseph was the primary developer for the PARSES pipeline for exogenous sequence discoveray and analysis
He is now a Software Developer at Savannah College of Art and Design in Savannah, GA- "Johnny" Jonathan Brown - BS, May 18, 2012
Johnny was a primary contributor to the Viamics framework for microbial community analysis
He is now working for a biotech company called Counsyl in San Francisco, CA
Counsyl provides universal genetic testing for prospective parents to council them on potential genetic diseases
Spring 2012: CSCI 1583 - Software Design and Development I
Spring 2012: CSCI 4401[G] - Principles of Operating Systems I
Fall 2011: CSCI 1583 - Software Design and Development I
Fall 2011: CSCI 2120 - Software Design and Development II
Spring 2011: CSCI 2120 - Software Design and Development II
Spring 2011: CSCI 4401[G] - Principles of Operating Systems I
Fall 2010: CSCI 1583 - Software Design and Development I
Fall 2010: CSCI 4401[G] - Principles of Operating Systems I
Spring 2010: CSCI 4401[G] - Principles of Operating Systems I
Fall 2009: CSCI 1583 - Software Design and Development I
Fall 2009: CSCI 4401[G] - Principles of Operating Systems I
Spring 2009: CSCI 4401[G] - Principles of Operating Systems I
Fall 2008: CSCI 4401[G] - Principles of Operating Systems I
I enjoy teaching, advising, solving problems, and writing code which is why I've chosen an academic position over several opportunities to work in industry. The biotechnology sector is at a very exciting stage of development and I look forward to forging collaborations with some of the researchers and companies which are currently pushing the envelope of personal health care diagnostics and new sequencing technologies.